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PolyAI vs Reply.iowhich AI support agent should you pick in 2026?

Enterprise voice assistants for call centers — natural conversations that resolve customer calls.

🎧SupportAutonomousSubscription
VoiceTool useMemoryRAG

AI sales engagement — multichannel sequences, Jason AI SDR, and inbox-warming for outbound at scale.

💼SalesSemi-autonomousFreemium · from $59
Tool useMemoryVoice

PolyAI vs Reply.io — specs

SpecPolyAIReply.io
Agent Rank73 / 100 (A)75 / 100 (A)
AutonomyAutonomousSemi-autonomous
PricingSubscription · Free tierFreemium · from $59
Open sourceNoNo
CapabilitiesVoice, Tool use, Memory, RAGTool use, Memory, Voice
Integrations3 apps6 apps
VerifiedVerifiedVerified
ReleasedSep 2024Sep 2025

Categories: PolyAISupport · Reply.ioSales

Agent Rank breakdown

PolyAI
Agent Rank
73/ 100
AA-tier
Autonomy fit
9
Capabilities
8
Integrations
4
Pricing value
9
Polish & maturity
7
Verifiability
7

Auto-computed from autonomy, capabilities, integrations, pricing, maturity and editorial verification. Updated every deploy. How is this computed?

Reply.io
Agent Rank
75/ 100
AA-tier
Autonomy fit
8
Capabilities
6
Integrations
8
Pricing value
6
Polish & maturity
7
Verifiability
10

Auto-computed from autonomy, capabilities, integrations, pricing, maturity and editorial verification. Updated every deploy. How is this computed?

Pros & cons

PolyAI
Reply.io
Pros
  • +Inbox warming is bundled — saves $10-30/mo vs Lemlist + Mailtoaster separately
  • +Jason AI SDR can run sequences autonomously, including reply handling
  • +Multichannel (email + LinkedIn + calls) in one UI, no swiveling
Cons
  • UI denser than Lemlist — steeper learning curve
  • AI SDR Jason is expensive on top of base plan
  • CRM integrations less polished than Outreach/Salesloft enterprise tier

Pricing

PolyAI
Reply.io
Free
Free
Trial
  • +200 monthly emails
  • +Email sequences
  • +Inbox warmup
Email Volume
$59/seat/mo
Email-first reps
  • +Unlimited sending mailboxes
  • +1,000 active contacts
  • +AI Email Assistant
Recommended
Multichannel
$99/seat/mo
Outbound teams
  • +LinkedIn automation
  • +Calls + SMS
  • +AI Jason SDR (limited)
Agency
$166/seat/mo
Lead agencies
  • +Up to 5,000 active contacts
  • +White label
  • +API access

Which one should you pick?

PolyAI

Pick PolyAI if cost is the main constraint or if you want the highest autonomy and the verification loop is in place.

Try PolyAI →
Reply.io

Pick Reply.io if your stack spans many tools and integration depth is the constraint.

Try Reply.io →

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Frequently asked

Should I pick PolyAI or Reply.io in 2026?+

Pick PolyAI if cost is the main constraint or if you want the highest autonomy and the verification loop is in place. Pick Reply.io if your stack spans many tools and integration depth is the constraint. Most working teams running both can use PolyAI for primary work and Reply.io for the workflows where its specific strengths matter.

What's the price difference between PolyAI and Reply.io?+

PolyAI starts at Subscription · Free tier; Reply.io starts at Freemium · from $59. PolyAI is the cheaper entry option. For team deployments the TCO can differ — use the AI Agent Rank TCO calculator for your specific volume.

Which is more autonomous, PolyAI or Reply.io?+

PolyAI is the more autonomous of the two (Autonomous vs Semi-autonomous). Higher autonomy ships throughput faster but requires verification loops in place — see our autonomous-vs-copilot framing for when each tier wins.

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Want the real monthly cost at your volume? Run the TCO calculator →
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PolyAI vs Reply.io (2026): which AI support agent wins? · AI Agent Rank